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Cytogenet Genome Res. 2004;105(2-4):316-24.

DNA methylation in mouse gametogenesis.

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Laboratoire de radiosensibilité des cellules germinales, Département de Radiobiologie et Radiopathologie, CEA/DSV/SEGG/LRCG Fontenay-aux-roses, France.


DNA methylation is involved in many biological processes and is particularly important for both development and germ cell differentiation. Several waves of demethylation and de novo methylation occur during both male and female germ line development. This has been found at both the gene and all genome levels, but there is no demonstrated correlation between them. During the postnatal germ line development of spermatogenesis, we found very complex and drastic DNA methylation changes that we could correlate with chromatin structure changes. Thus, detailed studies focused on localization and expression pattern of the chromatin proteins involved in both DNA methylation, histone tails modification, condensin and cohesin complex formation, should help to gain insights into the mechanisms at the origin of the deep changes occurring during this particular period.

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