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Fertil Steril. 2004 Jul;82(1):218-9.

Gonadotropin treatment of an azoospermic patient with a Y-chromosome microdeletion.

Author information

1
Istituto Europeo Medicina della Riproduzione Abruzzese, Spatocco Hospital, Chieti, Italy. selmanha@yahoo.com

Abstract

OBJECTIVE:

To report on the treatment with recombinant FSH of an azoospermic normogonadotropic patient with a Y-chromosome microdeletion.

DESIGN:

Case report.

SETTING:

An assisted reproduction center.

PATIENT(S):

A 32-year-old patient with azoospermia.

INTERVENTION(S):

Histological testicular biopsy, Y-chromosome screening, FSH treatment, and intracytoplasmic sperm injection.

MAIN OUTCOME MEASURE(S):

Fertilization, embryo development, pregnancy, and delivery.

RESULT(S):

After 6 months of treatment with gonadotropins, a small number of spermatozoa were found in the patient's ejaculate and used for IVF, resulting in a successful twin pregnancy and the delivery of two healthy girls.

CONCLUSION(S):

In this study, treatment with gonadotropins promoted the spermatogenesis process and led to the production of spermatozoa in a normogonadotropic azoospermic patient.

[Indexed for MEDLINE]

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