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Nat Med. 2004 Aug;10(8):813-5. Epub 2004 Jul 4.

Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity.

Author information

1
Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA.

Abstract

There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.

PMID:
15235599
DOI:
10.1038/nm1078
[Indexed for MEDLINE]

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