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J Ethnopharmacol. 2004 Aug;93(2-3):227-30.

Flavonol glycosides from the leaves of Eucommia ulmoides O. with glycation inhibitory activity.

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Food Function Research Division, Korea Food Research Institute, Kyonggi-do 463-746, Republic of Korea.


Eucommia ulmoides leaves have been used as a folk remedy for the treatment of diabetes in Korea. The aim of this study was to isolate and identify the compounds which inhibited advanced glycation end-product formation, one of main molecular mechanisms implicated in diabetic complications. A new flavonol glycoside, quercetin 3-O-alpha-L-arabinopyranosyl-(1-->2)-beta-D-glucopyranoside (1), and known flavonols kaempferol 3-O-beta-D-glucopyranoside (astragalin) (2), quercetin 3-O-beta-D-glucopyranoside (isoquercitrin) (3) were isolated from the leaves of Eucommia ulmoides. These compounds exhibited glycation inhibitory activity comparable to that of aminoguanidine, a known glycation inhibitor. The results suggest that the flavonol glycosides with glycation inhibitory activity could be attributed to the anti-diabetic action of Eucommia ulmoides leaves.

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