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Ophthalmology. 2004 Jul;111(7):1352-5.

Three-day application of topical ofloxacin reduces the contamination rate of microsurgical knives in cataract surgery: a prospective randomized study.

Author information

1
Department of Ophthalmology, School of Medicine, Stanford University, Stanford, California 94304, USA.

Abstract

PURPOSE:

To determine the rate of contamination of microsurgical knives during cataract surgery and the benefit of a 3-day versus a 1-hour preoperative application of topical ofloxacin in reducing the contamination rate.

DESIGN:

Prospective, randomized controlled trial.

PARTICIPANTS:

Seventy-eight eyes of 75 patients were randomly assigned to control (39 eyes) or study groups (39 eyes).

METHODS:

All patients from both groups received 0.3% topical ofloxacin 1 hour before surgery, 5% povidone-iodine (PVI) scrub of the periorbital area, and 2 drops of PVI onto the ocular surface preoperatively. The patients in the study group also received ofloxacin 4 times a day for 3 days before surgery.

MAIN OUTCOME MEASURES:

Microsurgical knives were placed in blood culture broth media immediately after the incision had been made. The number of positive cultures and types of bacteria isolated were determined.

RESULTS:

Ten of 39 knives (26%) in the control group were found to be positive for bacterial growth compared with only 2 of 39 (5%) in the study group (P = 0.028).

CONCLUSIONS:

The initial paracentesis incision frequently results in contamination of the microsurgical knife and may serve as a mechanism for introducing bacteria from the ocular surface into the anterior chamber. The application of topical ofloxacin for 3 days before surgery significantly reduces the contamination rate of the microsurgical knives, compared with a preoperative application of ofloxacin given 1 hour before surgery.

PMID:
15234136
DOI:
10.1016/j.ophtha.2003.10.032
[Indexed for MEDLINE]

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