Format

Send to

Choose Destination
Mol Ther. 2004 Jul;10(1):5-18.

Genetic modification of T lymphocytes for adoptive immunotherapy.

Author information

1
Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, 48129 Muenster, Germany. rossig@uni-muenster.de

Abstract

Adoptive transfer of T lymphocytes is a promising therapy for malignancies-particularly of the hemopoietic system-and for otherwise intractable viral diseases. Efforts to broaden the approach have been limited by the physiology of the T cells themselves and by a range of immune evasion mechanisms developed by tumor cells. In this review we show how genetic modification of T cells is being used preclinically and in patients to overcome these limitations, by incorporation of novel receptors, resistance mechanisms, and control genes. We also discuss how the increasing safety and effectiveness of gene transfer technologies will lead to an increase in the use of gene-modified T cells for the treatment of a wider range of disorders.

PMID:
15233937
DOI:
10.1016/j.ymthe.2004.04.014
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center