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Immunol Rev. 2004 Jun;199:40-53.

Targeting plasmid-encoded proteins to the antigen presentation pathways.

Author information

1
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Abstract

The antigen presentation pathways constitute a fulcrum on which adaptive immunity is balanced, and their manipulation should allow us to induce designer immune responses. The ease and rapidity with which DNA vaccines can be constructed and altered make them ideal candidates with which to test the various targeting strategies that have been conceived to date. These approaches and the mechanisms that may (or may not) underlie their success are reviewed in this article.

PMID:
15233725
DOI:
10.1111/j.0105-2896.2004.0135.x
[Indexed for MEDLINE]

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