Using osteoscopic, osteometric, radiographic and chemical methods, a study of long tubular bones (tibia) was performed to compare their parameters in Krasnoyarsk men that lived in XVII-XVIII centuries (50 observations) and at present time (30 observations). Main regularities of their variability were established taking into account the factor of time. Bones of modern men were found to have more expressed relief, greater values of osteometric parameters, among which the increase of longitudinal parameters was prevalent over the increase of width parameters and perimeters. The incidence of diaphyseal cross-sectional forms flattened in medial plane was increased, while the degree of bone mineralization was reduced with the appearance of a tendency towards decline of strength index. The data obtained demonstrate the gracilization of the skeleton of the modern city population and permit to distinguish the regional peculiarities of its variability.