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J Clin Invest. 2004 Jul;114(1):23-7.

Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?

Author information

1
Department of Pathology, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA. dickson.dennis@mayo.edu

Abstract

Increasing evidence suggests that selective neuronal loss in neurodegenerative diseases involves activation of cysteine aspartyl proteases (caspases), which initiate and execute apoptosis. In Alzheimer disease both extracellular amyloid deposits and intracellular amyloid beta protein may activate caspases, leading to cleavage of nuclear and cytoskeletal proteins, including tau protein. Proteolysis of tau may be critical to neurofibrillary degeneration, which correlates with dementia.

PMID:
15232608
PMCID:
PMC437977
DOI:
10.1172/JCI22317
[Indexed for MEDLINE]
Free PMC Article

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