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Am J Psychiatry. 2004 Jul;161(7):1290-2.

Prevention of postpartum depression: a pilot randomized clinical trial.

Author information

1
Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA. WisnerKL@upmc.edu

Abstract

OBJECTIVE:

The authors attempted to reduce the rate of postpartum depression in high-risk women and to increase the time to recurrence.

METHOD:

Nondepressed pregnant women with at least one past episode of postpartum major depression were recruited into a randomized clinical trial. Mothers were assigned randomly to a 17-week trial of sertraline or placebo immediately after birth and assessed for 20 sequential weeks with the Hamilton Rating Scale for Depression.

RESULTS:

Of 14 subjects who took sertraline, one (7%) suffered a recurrence. Of eight subjects who were assigned to placebo, four (50%) suffered recurrences. This difference was significant. The time to recurrence was significantly longer in the sertraline-treated women than in the placebo-treated women.

CONCLUSIONS:

Sertraline conferred preventive efficacy for postpartum-onset major depression beyond that of placebo.

PMID:
15229064
DOI:
10.1176/appi.ajp.161.7.1290
[Indexed for MEDLINE]

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