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Expert Rev Mol Diagn. 2004 Jul;4(4):443-53.

Type-specific testing for herpes simplex virus.

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Seattle HIV Prevention Trials Unit, 901 Boren Ave., Suite 1300, Seattle, WA 98104, USA.


The prevalence of genital herpes is increasing worldwide. Type-specific antibody tests for herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are widely available, however, only those based on glycoprotein G have acceptable accuracy. When diagnosing genital herpes, it is important to use type-specific tests in order to distinguish HSV-1 from HSV-2 since the type of HSV infection affects prognosis and subsequent counseling. Populations appropriate for type-specific serologic testing for HSV include people with an uncertain clinical diagnosis, high-risk patients, partners of an HSV-infected individual, HIV-infected individuals and pregnant women.

[Indexed for MEDLINE]

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