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J Neuroimmunol. 2004 Jul;152(1-2):121-5.

Regulation of IL-6 system in cerebrospinal fluid and serum compartments by seizures: the effect of seizure type and duration.

Author information

1
Department of Neurology and Rehabilitation, University of Tampere and Tampere University Hospital, 33521 Tampere, Finland. kai.lehtimaki@uta.fi

Abstract

Experimental studies suggest that cytokine production may be triggered by seizure activity. Here we determined the levels of interleukin-6 (IL-6) and its soluble receptor components (sIL-6R and sGp130) in CSF and serum from control subjects and patients after different types of seizures. IL-6 levels were increased after seizures, whereas sIL-6R levels were decreased. Interestingly, the levels of IL-6 were strongly increased after recurrent generalized tonic-clonic seizures (GTCS), whereas after single tonic-clonic or prolonged partial seizures IL-6 levels were increased to lesser extent. These results provide further support for a hypothesis of cytokine production induced by seizure activity per se.

PMID:
15223244
DOI:
10.1016/j.jneuroim.2004.01.024
[Indexed for MEDLINE]

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