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Trends Endocrinol Metab. 2004 Jul;15(5):211-4.

Genotoxicity of steroidal estrogens.

Author information

1
Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA. J_russo@fccc.edu

Abstract

The molecular mechanisms underlying the development of breast cancer in general, and estrogen-associated breast carcinogenesis in particular, are not completely understood. There are three mechanisms considered responsible for the carcinogenicity of estrogens in the human breast: (i) receptor-mediated hormonal activity, which stimulates cellular proliferation, resulting in more opportunities for accumulation of the genetic damage that leads to carcinogenesis; (ii) a cytochrome P450-mediated metabolic activation, which elicits direct genotoxic effects by increasing mutation rates; and (iii) the induction of aneuploidy by estrogen. In this article, we concentrate on discussing the role of estrogen receptors and the metabolic activation of 17beta-estradiol (E(2)) as mechanisms of breast cancer initiation.

PMID:
15223050
DOI:
10.1016/j.tem.2004.05.007
[Indexed for MEDLINE]

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