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Hum Biol. 2004 Feb;76(1):147-51.

Lack of Arg972 polymorphism in the IRS1 gene in Parakanã Brazilian Indians.

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1
Departamento de Clínica Médica, FCM-UNICAMP, Campinas, SP Brazil 13081-970.

Abstract

Several polymorphisms in the insulin receptor substrate-1 (IRS1) gene have been reported in the last years. The most common IRS1 variant, a Gly --> Arg substitution at codon 972 (Arg972 IRS1), is more prevalent among subjects who have features of insulin resistance syndrome associated, or not, with type 2 diabetes in European populations. To determine whether the absence of IRS1 polymorphism is a more general characteristic of Paleo-Indian-derived populations, we examined the Arg972 IRS1 polymorphism in Parakanã Indians and found a lack of this polymorphism in the Parakanã population.

PMID:
15222685
[Indexed for MEDLINE]
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