Format

Send to

Choose Destination
Trends Neurosci. 2004 Jul;27(7):415-21.

Orchestrating neuronal differentiation: patterns of Ca2+ spikes specify transmitter choice.

Author information

1
Neurobiology Section and Center for Molecular Genetics, Division of Biological Sciences, UCSD, La Jolla, CA 92093, USA. nspitzer@ucsd.edu

Abstract

Appropriate specification of neurotransmitters is a key feature of neuronal network assembly. There is much evidence that genetic programs are responsible for this aspect of cell fate and neuronal differentiation. Are there additional ways in which these processes are shaped? Recent findings demonstrate that altering patterned Ca(2+) spike activity that is spontaneously generated by different classes of embryonic spinal neurons in vivo changes expression of neurotransmitters in a homeostatic manner, as if to achieve a constant level of excitation. Activity-dependent changes in presynaptic transmitter expression pose a matching problem: are there corresponding changes in postsynaptic transmitter receptor expression, or are axons rerouted to novel targets with which functional synapses can be formed?

PMID:
15219741
DOI:
10.1016/j.tins.2004.05.003
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center