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Mult Scler. 2004 Jun;10 Suppl 1:S62; discussion 62-4.

Overview of European pilot study of interferon beta-Ib in primary progressive multiple sclerosis.

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University Hospital Vall d'Hebron, Unitat de Neuroimmunologia Clinica, Pg Val d'Hebron 119-129 (EUI-2a P.) E-08035, Barcelona, Spain.


This short monograph describes a trial of interferon beta-1b in patients with primary progressive multiple sclerosis (PPMS) or transitional MS. Designed as a randomized, placebo-controlled pilot, the trial randomly placed 73 eligible patients into two groups, placebo or interferon beta-1b 8 MIU given subcutaneously every other day for two years. Significant differences favouring interferon beta-1b in the MSFC score, T2 lesion volume and TI lesion volume at 24 months were observed. Further study of interferon beta-Ib therapy in PPMS patients in warranted.

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