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Biol Neonate. 2004;85(4):285-9. Epub 2004 Jun 8.

Surfactant protein B: structure and function.

Author information

1
Department of Pediatrics and Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94118-1245, USA. hawgood@itsa.ucsf.edu

Abstract

Pulmonary surfactant is a mixture of phospholipids, neutral lipids, and associated proteins. A specific phospholipid, dipalmitoylphosphatidylcholine, is predominantly responsible for the modulation of surface tension at the alveolar air-liquid interface, but other surfactant lipid and protein components play important roles in surfactant function and metabolism. This review will focus on just one of the apoproteins, surfactant protein B, with a description of protein structure and the actions of surfactant protein B on surfactant lipid membranes.

PMID:
15218284
DOI:
10.1159/000078169
[Indexed for MEDLINE]

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