Format

Send to

Choose Destination
See comment in PubMed Commons below
Cereb Cortex. 2005 Jan;15(1):49-57. Epub 2004 Jun 24.

Post-pubertal emergence of prefrontal cortical up states induced by D1-NMDA co-activation.

Author information

1
Center for Neuropharmacology and Neuroscience, 47 New Scotland Avenue, Albany Medical College (MC-136), Albany, New York 12208, USA. tsengky@mail.amc.edu

Abstract

Dopamine-glutamate interactions may contribute to persistent electrical activity in the prefrontal cortex (PFC). We tested whether a D1 modulation of NMDA function can result in persistent depolarization in vitro. D1-NMDA co-activation yielded depolarizing plateaus resembling in vivo up states in PFC pyramidal neurons recorded in slices from adult (PD 45-65), but not pre-pubertal (PD 29-38) rats. These plateaus required intracellular Ca2+, activation of L-type Ca2+ channels and protein kinase A. These events were eliminated by intracellular administration of the voltage-gated Na+ channel blocker QX-314 or by interrupting synaptic activity with bath application of tetrodotoxin or the AMPA antagonist CNQX, suggesting that they require both intrinsic and synaptic mechanisms. These recurrent depolarizations could constitute important elements in cortical information processing, allowing synaptic plasticity and memory functions. Acquiring these PFC D1-NMDA interactions after puberty may be a critical element for developing mature cognitive abilities.

PMID:
15217899
DOI:
10.1093/cercor/bhh107
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center