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Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W318-20.

PredictRegulon: a web server for the prediction of the regulatory protein binding sites and operons in prokaryote genomes.

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1
Computational & Functional Genomics Group, Centre for DNA Fingerprinting and Diagnostics, EMBnet India Node, Hyderabad 500076, India.

Abstract

An interactive web server is developed for predicting the potential binding sites and its target operons for a given regulatory protein in prokaryotic genomes. The program allows users to submit known or experimentally determined binding sites of a regulatory protein as ungapped multiple sequence alignments. It analyses the upstream regions of all genes in a user-selected prokaryote genome and returns the potential binding sites along with the downstream co-regulated genes (operons). The known binding sites of a regulatory protein can also be used to identify its orthologue binding sites in phylogeneticaly related genomes where the trans-acting regulator protein and cognate cis-acting DNA sequences could be conserved. PredictRegulon can be freely accessed from a link on our world wide web server: http://www.cdfd.org.in/predictregulon/.

PMID:
15215402
PMCID:
PMC441502
DOI:
10.1093/nar/gkh364
[Indexed for MEDLINE]
Free PMC Article
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