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Antimicrob Agents Chemother. 2004 Jul;48(7):2697-9.

Sustained-release formulation of doxycycline hyclate for prophylaxis of tick bite infection in a murine model of Lyme borreliosis.

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  • 1Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, P.O. Box 2087, Rampart Rd., Foothill Campus, Fort Collins, CO 80522, USA. naz2@cdc.gov

Abstract

The prophylactic potential of a single injection of sustained-release doxycycline hyclate (Atridox) was compared to that of a single oral dose of doxycycline hyclate in a murine model of Lyme borreliosis. Prophylaxis, as measured by the lack of cultivable spirochetes and demonstrable pathology, was noted for 43% of orally treated mice; in contrast, the sustained-release doxycycline hyclate completely protected mice from infection and resultant pathology.

PMID:
15215128
PMCID:
PMC434223
DOI:
10.1128/AAC.48.7.2697-2699.2004
[PubMed - indexed for MEDLINE]
Free PMC Article
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