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Clin Microbiol Infect. 2004 Jul;10(7):659-62.

High-level fluoroquinolone resistance in a clinical Streptoccoccus pyogenes isolate in Germany.

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Institute of Medical Microbiology, National Reference Centre for Streptococci, University Hospital, Aachen, Germany.


An isolate of Streptococcus pyogenes isolated from a 63-year-old woman with a serious wound infection was found to be highly resistant to fluoroquinolones (levofloxacin MIC > or = 32 mg/L). DNA amplification and sequencing revealed a serine-81 to phenylalanine substitution in gyrA and three substitutions in parC: serine-79 to phenylalanine, aspartic acid-91 to asparagine, and serine-140 to proline. To our knowledge, this is the first report from a European country of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance.

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