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Infect Immun. 2004 Jul;72(7):4275-8.

Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice.

Author information

1
Division of Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, MSB 6006, Cincinnati, OH 45267-0564, USA. gee.lau@uc.edu

Abstract

Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.

PMID:
15213173
PMCID:
PMC427412
DOI:
10.1128/IAI.72.7.4275-4278.2004
[Indexed for MEDLINE]
Free PMC Article
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