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Brain Res. 2004 Jul 16;1014(1-2):244-6.

Sex differences in systemic morphine analgesic tolerance following intrathecal morphine injections.

Author information

1
Neuropsychology Doctoral Subprogram, Queens College, City University of New York, Flushing, NY 11367, USA.

Abstract

Morphine analgesic potency following systemic administration was assessed in male and female mice undergoing prior and repeated intrathecal morphine injections. Although morphine ED50 values were significantly increased in both sexes relative to their respective saline-injected controls, the magnitude of tolerance was greater in females. Intrathecal injection alone had no effect on morphine analgesia. The data suggest that spinal mechanisms contribute to sex differences in analgesic tolerance following systemic morphine administration.

PMID:
15213009
DOI:
10.1016/j.brainres.2004.03.056
[Indexed for MEDLINE]

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