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J Immunol. 2004 Jul 1;173(1):15-9.

B cell positive selection: road map to the primary repertoire?

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  • 1Department of Pathology, University of Pennsylvania School of Medicine, John Morgan Building Room 284, 36th and Hamilton Walk, Philadelphia, PA 19104, USA. cancro@mail.med.upenn.edu

Abstract

Accumulating evidence indicates that positive selection events mediate differentiation, lineage commitment, and longevity of B lymphocytes. The BCR plays a central role, dictating the likelihood that newly formed cells will complete maturation, as well as whether cells persist within mature pools. Competition among B cells for limited, life span-promoting resources, which include self-ligands, lineage-specific cytokines, and innate receptor ligands, underlie these selective processes. Together, these observations suggest that positive selection is a critical feature in the establishment and maintenance of all lymphocyte pools, prompting re-evaluation of the underlying biological rationale for this process.

PMID:
15210753
[PubMed - indexed for MEDLINE]
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