Format

Send to

Choose Destination
Arch Otolaryngol Head Neck Surg. 2004 Jun;130(6):770-2.

Outcome of patients with positive Epstein-Barr virus serologic status in the absence of nasopharyngeal carcinoma in Hong Kong.

Author information

1
Department of Otorhinolaryngology-Head & Neck Surgery, St George's Hospital Medical School, University of London, London, England, United Kingdom. stephenlo@lycos.co.uk

Abstract

OBJECTIVE:

To evaluate the current clinical practice of follow-up and the outcomes of patients with raised Epstein-Barr virus (EBV) antibody levels but without pathological evidence of nasopharyngeal carcinoma (NPC) for a possible risk of developing NPC in the future.

DESIGN:

Retrospective review of prospectively collected database.

SETTING:

Tertiary referral otorhinolaryngology center.

PATIENTS:

The study population comprised 66 patients (27 male and 39 female; median age, 43.5 [range, 9-78] years) who presented in 1997 with a positive EBV IgA viral capsid antigen titer but a negative nasopharyngeal biopsy result.

MAIN OUTCOME MEASURES:

The detection of NPC and EBV seroconversion rate.

RESULTS:

Of the 66 patients studied, 14 had a positive family history of NPC. Fourteen patients (27%) were excluded because of loss of contact or refusal of follow-up. The median follow-up period of the remaining 52 patients was 54.5 months (range, 12-64 months). Of these 52 patients, 39 (75%) had initial nasendoscopic finding described as completely normal. During the follow-up period, NPC was diagnosed in 1 patient (2%) 18 months after first biopsy. The initial nasendoscopy and histological findings in this patient were normal despite the patient having a raised EBV IgA VCA titer of 1:640. Overall, the EBV serologic status of 36 patients (69%) reverted to normal within the studied period (median interval of 54.5 [range, 12-64] months).

CONCLUSIONS:

In the median follow-up period of 54.5 months, only 1 patient (2%) developed NPC. A significant proportion of the patients seroconverted back to normal, none of whom developed NPC.

PMID:
15210561
DOI:
10.1001/archotol.130.6.770
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center