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Biochem J. 2004 Aug 1;381(Pt 3):593-7.

Heparan sulphate identified on human erythrocytes: a Plasmodium falciparum receptor.

Author information

1
Microbiology and Tumorbiology Center, Karolinska Institutet, Box 280, SE-171 77 Stockholm, Sweden. Anna.Vogt@mtc.ki.se

Abstract

HS (heparan sulphate) has hitherto not been found on human red blood cells (RBCs, erythrocytes). However, malarial-parasite (Plasmodium falciparum)-infected RBCs adhere to uninfected RBCs via HS-like receptors. In the present paper we demonstrate that human RBCs carry epitopes for an anti-HS antibody. Glycans isolated from RBC membranes reacted to HS-specific degradations and adhered to an HS-binding malaria antigen. Additionally, an HS core protein was identified. This suggests that HS is present on human RBCs.

PMID:
15209561
PMCID:
PMC1133867
DOI:
10.1042/BJ20040762
[Indexed for MEDLINE]
Free PMC Article

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