Abstract
It was reported that three polymorphic genes were identified to be able to potentially influence the bioaccumulation and toxicokinetics of lead in humans. These genes are delta-aminolevulinic acid dehydratase(ALAD) gene, vitamin D receptor (VDR) and hemochromatosis gene. Their relation to susceptibility to lead poisoning in humans was reviewed in this paper.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Environmental Exposure
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GPI-Linked Proteins
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Genetic Predisposition to Disease*
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Hemochromatosis / genetics
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Hemochromatosis Protein
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Humans
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Lead Poisoning / genetics*
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Membrane Proteins / genetics
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Occupational Exposure
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Polymorphism, Genetic
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Porphobilinogen Synthase / genetics*
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Receptors, Calcitriol / genetics*
Substances
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GPI-Linked Proteins
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HJV protein, human
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Hemochromatosis Protein
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Membrane Proteins
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Receptors, Calcitriol
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Porphobilinogen Synthase