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Neuroreport. 1992 Aug;3(8):713-6.

Age-related shrinkage of the mamillary bodies: in vivo MRI evidence.

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Department of Psychology, Memphis State University, TN 38152.


Mamillary body (MB) is a diencephalic structure hypothesized to be involved in memory, a cognitive function that declines with age. In this study, age-related differences in the size of MB were examined in vivo using magnetic resonance (MR) imaging. The cross-sectional area of the MB was estimated from MR images of the brain in healthy volunteers and neurologically intact patients (age 18-78). The cross-sectional area of the tectum was used as a control region of interest. We found a significant age-related reduction in the area of the MB, but not of the tectum. No sex differences were observed in the size of either structure.

[Indexed for MEDLINE]

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