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J Affect Disord. 2004 Jun;80(2-3):135-44.

Residual symptoms at remission from depression: impact on long-term outcome.

Author information

1
Department of Psychiatry, University of Cambridge, Cambridge, UK. n.kennedy@iop.kcl.ac.uk

Abstract

BACKGROUND:

Although residual symptoms after remission from depression are common and predict early relapse, little is known about the impact of residual symptoms on longer-term clinical course of depression or social functioning.

METHODS:

Sixty severe recurrent depressives, who remitted from an index episode of depression with residual symptoms or below residual symptomatology, were followed-up at 8-10 years. Subjects underwent detailed longitudinal interviewing on course of depression, treatment and socioecomonic functioning over follow-up.

RESULTS:

Long-term follow-up data was obtained on all living subjects and 55 (95%) were interviewed. The residual symptoms group spent more time with depressive symptoms over follow-up but not at full criteria for major depression and showed greater impairment in longitudinal and follow-up social adjustment. No significant differences were found between the two groups in percentage recurring long-term, mean number of recurrences, readmissions, chronic episodes or clinical global outcome criteria.

LIMITATIONS:

Long-term clinical and social outcomes were assessed by a single retrospective longitudinal interview.

CONCLUSIONS:

Patients who remit from depression with residual symptomatology continue to have more depressive symptoms and impaired social functioning long-term and may need more aggressive treatment.

PMID:
15207926
DOI:
10.1016/S0165-0327(03)00054-5
[Indexed for MEDLINE]
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