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Res Microbiol. 2004 Jun;155(5):399-408.

Large-scale genome remodelling by the developmentally programmed elimination of germ line sequences in the ciliate Paramecium.

Author information

1
CNRS UMR 8541, Laboratoire de Génétique Moléculaire, Ecole Normale Supérieure, 46 rue d'Ulm, 75005 Paris, France. betermie@biologie.ens.fr

Abstract

In Paramecium, during the development of the somatic macronucleus, precise excision of thousands of single-copy non-coding sequences is initiated by specific DNA double-strand breaks, while imprecise elimination of germ-line-limited repeated sequences leads to internal deletions or chromosome fragmentation. Recent data point to a role of non-coding RNAs in the epigenetic programming of these rearrangements.

PMID:
15207872
DOI:
10.1016/j.resmic.2004.01.017
[Indexed for MEDLINE]

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