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Tuberculosis (Edinb). 2004;84(3-4):256-62.

Regulation of the Mycobacterium tuberculosis PE/PPE genes.

Author information

1
Department of Microbiology, University of Colorado Health Sciences Center, Denver 80262, USA. martin.voskuil@uchsc.edu

Abstract

The genome of Mycobacterium tuberculosis encodes approximately 170 members of the unique mycobacterial PE and PPE gene families. Evidence suggests members of these families are surface-associated cell wall proteins that may provide a diverse antigenic profile and affect immunity. To determine if the expression patterns of PE/PPE genes are consistent with a role in antigenic variability, we analyzed microarray data from 132 experimental conditions for expression of PE/PPE genes. Whole genome expression patterns show that the PE/PPE genes are regulated in a variable and largely independent manner. Gene expression profiling of 15 unique conditions identified differential regulation of 128 of the 169 PE/PPE genes. Expression of the PE/PPE genes appears to be controlled by a variety of independent mechanisms. These data indicate that differential expression of the PE/PPE genes has the potential to provide a dynamic antigenic profile during the course of changing microenvironments within the host.

PMID:
15207495
DOI:
10.1016/j.tube.2003.12.014
[Indexed for MEDLINE]

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