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Neurobiol Dis. 2004 Jun;16(1):59-67.

Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP.

Author information

1
Center for Neurologic Diseases, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA. morin@bu.edu

Abstract

The metabolism of amyloid precursor protein (APP) is central to Alzheimer's disease pathogenesis. Recent data have linked APP and presenilin to the Wnt/wingless signaling pathway. To assess affects of Wnt stimulation on APP isoform expression, we infected PC12 cells and C57MG cells with a retrovirus containing murine Wnt-1. In PC12 cells, Wnt-1 expression is associated with induction of exon 15 deletion from APP mRNA and expression of L-APP. Our data suggest that APP isoform expression is regulated, in part, by the Wnt/wingless signaling pathway.

PMID:
15207262
DOI:
10.1016/j.nbd.2004.01.004
[Indexed for MEDLINE]

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