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Br J Clin Pharmacol. 2004 Jul;58(1):66-70.

Thiopurine S-methyltransferase genetic polymorphism in the Thai population.

Author information

1
Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

Abstract

AIMS:

To determine the incidence of the thiopurine S-methyltransferase (TPMT) genetic polymorphism in the Thai population.

METHODS:

Genomic DNAs were isolated from peripheral blood leucocytes of 200 healthy Thais. The frequencies of five allelic variants of the TPMT gene, TPMT*2, *3A, *3B, *3C and *6 were determined using allele specific polymerase chain reaction (PCR) or PCR-Restriction fragment length polymorphism technique.

RESULTS:

Of the 200 Thai subjects participating in this study, 181 subjects (90.5%) were homozygous for TPMT*1, 18 subjects (9.0%) were heterozygous for TPMT*1/*3C. Only one subject (0.5%) was homozygous for TPMT*3C. The frequency of TPMT*3C mutant allele was 0.050.

CONCLUSIONS:

Although the TPMT*3C is the most prevalent mutant allele in Asian populations, the frequency of this defective allele is significantly higher in Thais than has been reported in other Asian populations.

PMID:
15206995
PMCID:
PMC1884540
DOI:
10.1111/j.1365-2125.2004.02112.x
[Indexed for MEDLINE]
Free PMC Article

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