Send to

Choose Destination
See comment in PubMed Commons below
Eur Arch Psychiatry Clin Neurosci. 2004 Jun;254(3):143-7.

Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism.

Author information

  • 1Gaziantep Typ Fakultesi, Kolejtepe Binasi, Cocuk ve Ergen Psikiyatrisi AD, Kolejtepe, 27200 Gaziantep, Turkey.


There is great evidence in recent years that oxygen free radicals play an important role in the pathophysiology of many neuropsychiatric disorders. The present study was performed to assess the changes in red blood cells thiobarbituric acid-reactive substances (TBARS) levels, and superoxide dismutase (SOD), catalase (CAT), adenosine deaminase (ADA) and xanthine oxidase (XO) activities in patients with autism (n = 27) compared to age- and sex-matched normal controls (n = 26). In the autistic group, increased TBARS levels (p < 0.001) and XO (p < 0.001) and SOD (p < 0.001) activity, decreased CAT (p < 0.001) activity and unchanged ADA activity were detected. It is proposed that antioxidant status may be changed in autism and this new situation may induce lipid peroxidation. These findings indicated a possible role of increased oxidative stress and altered enzymatic antioxidants, both of which may be relevant to the pathophysiology of autism.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center