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Mediators Inflamm. 2004 Feb;13(1):21-4.

Suppression of neutrophil recruitment in mice by geranium essential oil.

Author information

1
Teikyo University Institute of Medical Mycology, Hachioji, Tokyo, Japan. sabe@main.teikyo-u.ac.jp

Abstract

BACKGROUND:

In aromatherapy, essential oils are used as anti-inflammatory remedies, but experimental studies on their action mechanisms are very limited.

AIMS OF THE STUDY:

To assess their anti-inflammatory activities, the effects of essential oils on neutrophil recruitment in mice were examined in vivo.

METHOD:

The effect of essential oils on leukocyte and neutrophil recruitment induced 6 h after intraperitoneal injection of casein in mice was examined.

RESULTS:

Leukocyte recruitment into the peritoneal cavity in mice was suppressed by intraperitoneal injections of geranium, lemongrass and spearmint oils at the dose of 5 microl/mouse, but was not by tea tree oil. This recruitment was inhibited dose-dependently by geranium oil. The suppression of leukocyte recruitment resulted from inhibition of neutrophil accumulation.

CONCLUSION:

Some essential oils used as anti-inflammatory remedies suppress neutrophil recruitment into the peritoneal cavity in mice.

PMID:
15203560
PMCID:
PMC1781532
DOI:
10.1080/09629350410001664798
[Indexed for MEDLINE]
Free PMC Article

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