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Cell Immunol. 2004 Mar;228(1):8-14.

Normal differentiation and functions of mouse dendritic cells derived from RAG-deficient bone marrow progenitors.

Author information

1
Laboratoire d'Immunochimie, Institut National de la Santé et de la Recherche Médicale, Unité 548, Commissariat à l'Energie Atomique de Grenoble, Université Joseph Fourier, 38000 Grenoble, France. mfaure@cea.fr

Abstract

Dendritic cells (DC) mature upon infectious agent detection to elicit immune responses. It has been suggested that T cells influence peripheral DC function. However, it is not known if lymphocytes influence DC progenitors. Therefore, we determined the ability of bone marrow progenitors from T and B cell-deficient mice to generate functional DC. We report that bone marrow-derived DC from RAG-2(-/-) mice differentiate and proliferate normally. Moreover, such generated DC efficiently internalize particles, mature in response to various Toll-like receptor engagement, and activate allogenic T cells. This work strongly supports that early signals delivered during DC ontogeny by mature lymphocytes do not influence the functional differentiation of DC progenitors.

PMID:
15203314
DOI:
10.1016/j.cellimm.2004.04.002
[Indexed for MEDLINE]

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