Format

Send to

Choose Destination
Emerg Infect Dis. 2004 May;10(5):889-94.

Causative agent of Pogosta disease isolated from blood and skin lesions.

Author information

1
Department of Virology, Faculty of Medicine, Haartman Institute, University of Helsinki, Helsinki, Finland. satu.kurkela@helsinki.fi

Abstract

Pogosta disease is a mosquito-borne viral disease in Finland, which is clinically manifested by rash and arthritis; larger outbreaks occur in 7-year intervals. The causative agent of the disease has been suspected of being closely related to Sindbis virus (SINV). We isolated SINV from five patients with acute Pogosta disease during an outbreak in fall 2002 in Finland. One virus strain was recovered from a whole blood sample and four other strains from skin lesions. The etiology of Pogosta disease was confirmed by these first Finnish SINV strains, which also represent the first human SINV isolates from Europe. Phylogenetic analysis indicates that the Finnish SINV strains are closely related to the viral agents that were previously isolated from mosquitoes and that are related clinically similar diseases in nearby geographic areas.

PMID:
15200824
PMCID:
PMC3323234
DOI:
10.3201/eid1005.030689
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for CDC-NCEZID Icon for PubMed Central
Loading ...
Support Center