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Emerg Infect Dis. 2004 May;10(5):842-7.

Virulence factors for hemolytic uremic syndrome, Denmark.

Author information

1
Danish National Institute of Infectious Diseases, Statens Serum Institut, Copenhagen, Denmark. set@ssi.dk

Abstract

We present an analysis of strain and patient factors associated with the development of bloody diarrhea and hemolytic uremic syndrome (HUS) among Shiga toxin-producing Escherichia coli (STEC) patients registered in Denmark in a 6-year period. Of 343 STEC patients, bloody diarrhea developed in 36.4% and HUS in 6.1%. In a multivariate logistic regression model, risk factors for bloody diarrhea were the eae and stx2 genes, O groups O157 and O103, and increasing age. Risk factors for HUS were presence of the stx2 (odds ratio [OR] 18.9) and eae (OR undefined) genes, being a child, and having bloody diarrhea. O group O157, although associated with HUS in a univariate analysis (OR 4.0), was not associated in the multivariate analysis (OR 1.1). This finding indicates that, rather than the O group, the combined presence of the eae and stx2 genes is an important predictor of HUS.

Comment in

PMID:
15200817
PMCID:
PMC3323205
DOI:
10.3201/eid1005.030576
[Indexed for MEDLINE]
Free PMC Article

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