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Curr Opin Cell Biol. 2004 Apr;16(2):140-5.

Setting up a selective barrier at the apical junction complex.

Author information

1
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. jandersen@med.unc.edu

Abstract

Across the animal kingdom the apical junction complex of epithelial cells creates both a permeability barrier and cell polarity. Although based on overlapping and evolutionarily conserved proteins, the cell-cell contacts of nematodes, flies and mammals appear to differ in morphology and functional organization. Emerging evidence shows that the selective pore-like properties of vertebrate and invertebrate barriers are created by the claudin family. Similarly, assembly of the barriers requires a conserved set of polarity-generating protein complexes, particularly the PAR protein complexes.

PMID:
15196556
DOI:
10.1016/j.ceb.2004.01.005
[Indexed for MEDLINE]

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