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Immunol Invest. 2004 May;33(2):109-42.

The interleukin (IL)-2 family cytokines: survival and proliferation signaling pathways in T lymphocytes.

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1
Department of Oral Biology, University at Buffalo, SUNY, Buffalo, New York 14214, USA.

Abstract

Lymphocyte populations in the immune system are maintained by a well-organized balance between cellular proliferation, cellular survival and programmed cell death (apoptosis). One of the primary functions of many cytokines is to coordinate these processes. In particular, the interleukin (IL)-2 family of cytokines, which consists of six cytokines (IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21) that all share a common receptor subunit (gammac), plays a major role in promoting and maintaining T lymphocyte populations. The details of the molecular signaling pathways mediated by these cytokines have not been fully elucidated. However, the three major pathways clearly involved include the JAK/STAT, MAPK and phosphatidylinositol 3-kinase (P13K) pathways. The details of these pathways as they apply to the IL-2 family of cytokines is discussed, with a focus on their roles in proliferation and survival signaling.

PMID:
15195693
DOI:
10.1081/imm-120030732
[Indexed for MEDLINE]

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