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Nat Immunol. 2004 Jul;5(7):721-9. Epub 2004 Jun 13.

Critical functions for c-Myb at three checkpoints during thymocyte development.

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The Department of Microbiology, PO Box 800734, University of Virginia Health System, Charlottesville, Virginia 22908-0734, USA.


The transcription factor c-Myb is expressed throughout T cell development in the thymus. However, little is understood about c-Myb function because of the embryonic lethality of traditional Myb-null mutations. Using tissue-specific deletion to abrogate c-Myb expression at distinct stages of T cell development, we identify three points at which c-Myb activity is required for normal T cell differentiation: transition through the double-negative 3 stage, survival of preselection CD4(+)CD8(+) thymocytes, and differentiation of CD4 thymocytes. Thus, c-Myb is essential at several stages during T cell development in the thymus.

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