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Biomed Pharmacother. 2004 Jun;58(5):292-8.

A role of FcgammaRIIB in the development of collagen-induced arthritis.

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Department of Experimental Immunology and CREST program of Japan Science and Technology Agency, Institute of Development, Aging and Cancer, Tohoku University, Seiryo 4-1, Sendai 980-8575, Japan.


Immune inhibitory receptors play an important role in the maintenance of adequate activation threshold of various cells in our immune system. The inhibitory Fc receptor, type IIB Fc receptor for IgG (FcgammaRIIB), is one of the critical molecules for the regulation of immune responses through antibodies. Analysis of murine models indicates that FcgammaRIIB plays an essential role in the suppression of various autoimmune disorders. Recent studies reveal the novel regulatory role of FcgammaR in the development of collagen-induced arthritis (CIA), an animal model relevant to human rheumatoid arthritis (RA). This review provides an overview of FcgammaRIIB-mediated immune regulation, highlighting the implication of FcgammaRIIB in the selection of peripheral B cell development during the CIA course.

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