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Vaccine. 2004 Jun 23;22(19):2489-93.

Enhancement of DNA vaccine potency in rhesus macaques by electroporation.

Author information

1
Vaccines Research, Chiron Corporation, 4560 Horton St., Mail Stop 4-3, Emeryville, CA 94068, USA.

Abstract

The potency of an HIV DNA vaccine was enhanced in rhesus macaques by in vivo electroporation, as judged by increased onset, magnitude and duration of antibody and cell-mediated immune responses against both components of a combination Gag and Env vaccine. These data demonstrate the utility of the electroporation technology for use in large animals.

PMID:
15193413
DOI:
10.1016/j.vaccine.2003.11.073
[Indexed for MEDLINE]

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