Format

Send to

Choose Destination
See comment in PubMed Commons below
Annu Rev Biochem. 2004;73:705-48.

Mechanical processes in biochemistry.

Author information

1
Howard Hughes Medical Institute and the Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3206, USA. carlos@alice.berkeley.edu

Abstract

Mechanical processes are involved in nearly every facet of the cell cycle. Mechanical forces are generated in the cell during processes as diverse as chromosomal segregation, replication, transcription, translation, translocation of proteins across membranes, cell locomotion, and catalyzed protein and nucleic acid folding and unfolding, among others. Because force is a product of all these reactions, biochemists are beginning to directly apply external forces to these processes to alter the extent or even the fate of these reactions hoping to reveal their underlying molecular mechanisms. This review provides the conceptual framework to understand the role of mechanical force in biochemistry.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center