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Electrophoresis. 2004 Jun;25(10-11):1485-7.

Interferences in clinical capillary zone electrophoresis of serum proteins.

Author information

1
Laboratory Medicine/Immunology, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium. xavier.bossuyt@uz.kuleuven.ac.be

Abstract

Capillary zone electrophoresis (CZE) of serum proteins has become a well-accepted method for the separation of serum proteins and for the detection of monoclonal proteins in clinical laboratories. As CZE uses ultraviolet detection for direct protein quantification, exogenous ultraviolet-absorbing substances are a novel challenge, not present in conventional gel-based methods in which protein is quantified by dye binding. This minireview gives a survey of interfering substances, including iodinated contrast agents and antibiotics.

PMID:
15188230
DOI:
10.1002/elps.200305820
[Indexed for MEDLINE]

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