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Epilepsia. 2004;45 Suppl 2:15-21.

The treatment of nonepileptic seizures: historical perspectives and future directions.

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Brown Medical School, Rhode Island Hospital, Departments of Psychiatry and Neurology, Providence, Rhode Island 02903, USA.


Nonepileptic seizures (NES) are neuropsychiatric disorders presenting with a combination of neurologic signs and underlying psychological conflicts. For more than a century, the medical community has accumulated data and insights about the phenomenology, epidemiology, risks, comorbidities, and prognosis of NES. However, we have not progressed much beyond anecdotal reports of treatments for NES, and no randomized, controlled trials of treatment for the disorder have been conducted. We review the diagnosis and treatment of NES and suggest directions for future research in these areas.

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