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Immunol Cell Biol. 2004 Jun;82(3):307-14.

CD1d-restricted T-cell subsets and dendritic cell function in autoimmunity.

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Diabetes Research Laboratories, Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA.


CD1-restricted T cells have been shown to play a critical role in host defence, tumour surveillance, and maintenance of tolerance. However, immunologic outcomes resulting from activation of CD1d-restricted T cells can be either beneficial or deleterious. A major mechanism by which CD1d-restricted T cells are thought to exert immunoregulatory control is via effects on dendritic cell (DC) differentiation and migration. Important functional subsets of CD1d-restricted T cells are also known to exist and the potential implications for preferential subset activations are discussed.

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