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Immunol Cell Biol. 2004 Jun;82(3):247-52.

Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies.

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1
Department of Microbiology and Immunology, University of Melbourne, Royal Parade, Parkville, Victoria, Australia. berzins@unimelb.edu.au

Erratum in

  • Immunol Cell Biol. 2004 Jun;82(3):342.

Abstract

In the diabetes-prone NOD mouse, there is a proven association between a systemic deficiency of NKT cells and the onset of type 1 diabetes. Numerous reports of similar defects within the NKT cell compartment of human type 1 diabetes patients suggested NKT cell levels might be a valuable predictor of susceptibility and could provide a target for therapeutic intervention. Two recent studies, however, found no association between type 1 diabetes and blood NKT cell levels in humans and consequently rejected a link between the onset of diabetes and NKT cell deficiency. This cast considerable doubts on the potential for NKT cell-based clinical applications and challenged the validity of the NOD mouse as a model of human type 1 diabetes. We now report that NKT cell levels in blood are a poor representation of those in other organs. Strikingly, systemic NKT cell deficiencies were identified in NOD mice with normal, or even raised, blood levels. This re-establishes the correlation between NKT cell deficiency and type 1 diabetes and raises important questions regarding the assaying of NKT cell levels in humans.

[Indexed for MEDLINE]

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