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Nat Neurosci. 2004 Jul;7(7):697-8. Epub 2004 Jun 6.

Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus.

Author information

1
Program in Neuroscience and Department of Physiology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201, USA.

Abstract

In hippocampal pyramidal cells, a rise in Ca(2+) releases endocannabinoids that activate the presynaptic cannabinoid receptor (CB1R) and transiently reduce GABAergic transmission-a process called depolarization-induced suppression of inhibition (DSI). The mechanism that limits the duration of endocannabinoid action in intact cells is unknown. Here we show that inhibition of cyclooxygenase-2 (COX-2), not fatty acid amide hydrolase (FAAH), prolongs DSI, suggesting that COX-2 limits endocannabinoid action.

PMID:
15184902
DOI:
10.1038/nn1262
[Indexed for MEDLINE]

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