Format

Send to

Choose Destination
Neurology. 2004 Jun 8;62(11):2127-9.

Low levels of the vascular endothelial growth factor in CSF from early ALS patients.

Author information

1
Department of Neurology, R. Salengro Hospital, Lille, France.

Abstract

Deletion of the hypoxia-response element in the vascular endothelial growth factor (VEGF) promoter causes motor neuron degeneration in a mouse model. "At-risk" haplotypes with low circulating VEGF levels have been demonstrated in humans. Here the authors report low VEGF levels in the CSF of ALS patients during their first year of the disease, independently of VEGF promoter polymorphism. This finding early in ALS patients suggests a possible role for VEGF gene regulation in the pathogenesis of ALS.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center